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AGENDA |
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09:00 |
Opening Address and Day 1 Highlights by Chairperson |
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Dr Pauline Ng
POLARIS@GIS, Asia Genomics & NovogeneAIT
Pauline Ng is a seasoned pioneer in precision medicine with 15 years of experience and over 12,000 citations for her publications. With distinguished achievements in research, industry, and clinical settings, her breadth and depth is unparalleled. Her research accomplishments include characterizing the first personal human genome as an Assistant Professor at the J. Craig Venter Institute. She published a critical assessment of 23andMe’s direct-to-consumer personalized genetic test in Nature, as well as an article comparing next-generation sequencing technologies which was one of the year’s most-viewed articles in Genome Biology. Dr. Ng left her mark on industry during her tenure at Illumina, where she designed the content of the HumanHap BeadChips. Thanks to her superior design and on-time delivery, the product outperformed the competition and now accounts for the majority of genome-wide association studies. Dr. Ng also shaped the clinical landscape of Southeast Asia as a Group Leader at the Genome Institute of Singapore and the CIO of the POLARIS program. POLARIS was the first laboratory in Southeast Asia to be clinically certified for next-generation sequencing assays.
Her research interests include disease mutations, health trends in social media, and promoting open access to scientific literature. Dr. Ng received her PhD from the University of Washington. Her PhD thesis was the SIFT algorithm, which has been adopted by more than 100 pharma and biotech companies and is a staple algorithm for genetic disease. Dr. Ng is currently consulting.
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09:10 |
Opening Keynote Address: The Impact of Precision Medicine in Healthcare
- Understand the bedrock of Precision Medicine: Patient Centred, Information Intensive & Resource Development
- How Precision Medicine can Re-write the Future of Medicine
- Explore new paradigm, risks & opportunities in the Precision Medicine arena
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A/Prof Sonia Maria Davila Dominguez
Principal Investigator and Admin Lead, Institute of Precision Medicine (PRISM)
SingHealth Duke-NUS
Sonia Davila completed her undergraduate and graduate studies in Spain. The theme of her PhD thesis was “Molecular Genetics of inherited cystic kidney diseases”. Using a combination of linkage approaches and Sanger sequencing she identified new mutations in genes causing Autosomal dominant polycystic disease present only in Spanish families. Upon graduation she moved to Yale University (2001), to work with Prof Stephan Somlo on a subset of families diagnosed with a cystic disease affecting the liver. During those years she participated actively on the identification of two human genes causing Polycystic Liver Disease (PLD).
In 2004 she joined the Genome Institute of Singapore as a postdoctoral fellow on nephrogenomics, She was promoted to Research Scientist on 2007 and to Principal Investigator on 2010. Her work focused on human genetic susceptibility to infectious diseases. During that time she published several reports on new genetic variants associated to genetic susceptibility to meningococcal disease, Kawasaki disease, pulmonary tuberculosis and Dengue. Over the last two years she’s been also working on rare disorders, using NGS approaches to identify mutations in unique patients.
Her current work at SingHealth Duke-NUS Institute of Precision Medicine (PRISM) aims to implement Precision Medicine in a clinical setting. Sonia is an Adjunct Associate Professor at Duke-NUS and an Honorary Senior Research Fellow at Imperial College London.
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09:55 |
The Reliability and Challenges of Precision Medicine
- Discover the impacts of genomic medicine in the practice of medicine
- Understand the complexities of genetic composition and sequencing in Asia
- Realising the clinical implementation of genomics in Asia
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Dr Allen Lai
Senior Vice President & Regional MD
ACT Genomics
Dr. Allen Lai is now the senior vice president of ACT Genomics Singapore, strategizing corporate development, planning and execution of cancer genomics clinical & research projects in Southeast Asia. Allen has been frequently invited to speak on the topic of precision medicine in regional high level conferences such as Financial Times Healthcare Summit, International Conference in Cancer Control. He holds several high key profile roles as Advisor Board of ISPOR (International Society for Pharmacoecnomics and Outcomes Research) Asia Consortium, former President of ISPOR Singapore and concurrently Senior Consultant, Ministry of Health and Social Welfare, Taiwan. He received his Ph.D. and MPA, from Lee Kuan Yew School of Public Policy, National University of Singapore, M.Sc. (Preventive Medicine) from National Taiwan University and M.D. from Chung Shan Medical Dental University, Taiwan. He was the principal consultant at IMS Health Asia, and the director of Institute of Health Economics & Management and the academic director of MSc Management of Health Industries in ESSEC Business School.
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10:35 |
Morning Refreshments & Networking Session |
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11:00
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How do we Implement Precision Medicine in the Real World?
- Overcoming the challenges of translating next generation sequencing technology from research into clinic
- Address other barriers to implementing Precision Medicine (organization silos, policy)
- How to encourage the uptake of Precision Medicine as the Standard of Care
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Dr Bertil Lindmark
Chief Medical Officer
ASLAN Pharmaceutical
Dr Bertil Lindmark is Chief Medical Officer of ASLAN Pharmaceuticals. In his most recent position as Executive Director of Research and Development and Member of the Board of Directors at Almirall, a European pharmaceutical company with global reach, he led the global R&D team of more than 500 R&D staff across three sites, focusing on respiratory, gastrointestinal, dermatology and neuroscience. He secured EU and US approval of several important new drugs, including Eklira/Tudorza, Constella and Eklira/formoterol, and was instrumental in the USD$2bn sale of Almirall’s respiratory franchise to AstraZeneca.
Prior to Almirall, Bertil was VP at AstraZeneca, leading global clinical development in Respiratory and Inflammation, notably securing the global approval of Symbicort Turbuhaler. He also served as VP and Head of Clinical Development at AstraZeneca Japan R&D leading 170 staff. During his career, Bertil has been responsible for the global approval of 10 drugs, with sales exceeding USD$4bn across three compounds into man.
Bertil holds a MD degree and PhD in Molecular Epidemiology from the University of Lund, and specialist qualification in Internal Medicine and in Gastroenterology.
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11:30 |
Applying Precision Medicine Outside of Cancer
- Discover how Precision Medicine and Genomic Medicine can be applied in areas other than cancer
- New Clinical Developments on Biomarkers
- Case Study: Precision Medicine’s potential in obesity & NCD studies
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Dr Liu Jian Jun
Deputy Executive Director & Senior Group Leader, Human Genetics
Genome Institute of Singapore (GIS)
Dr. Liu is currently the Deputy Executive Director and Senior Group Leader (Human Genetics) at the Genome Institute of Singapore (GIS). Dr. Liu got his PhD on quantitative genetics at the Duke University and did his postdoctoral training in the genetics of psychiatric disorders at the Columbia University.
Dr Liu’s main research interest is to understand the genetic basis of human inheritance and disease susceptibility. Focusing on Asian populations, he pursues collaborative research to discover genetic variants that influence disease susceptibility, progression and treatment outcome by employing both candidate gene-based and genome-wide association analyses. His research covers diverse disease phenotypes, including cancers, autoimmune and inflammatory diseases, neurological and psychiatric disorders, cardiovascular diseasses, and infectious diseases and has led to the discovery of many novel susceptibility genes for human diseases and more recently treatment outcome. In addition, because the extent and distribution of disease predisposing genetic variation in human population is the result of a long and complicated evolutionary, migratory, and demographic history, he is also interested in investigating population processes affecting genetic variations in modern human populations. Such population genetics research can not only improve the understanding of the population structure of modern Human populations, but also further facilitate studies of complex diseases. Recently, Dr Liu’s research is focusing more on large-scale whole genome sequencing studies where large-scale genomic data are being explored for the improvement of clinical and healthcare services, such as various Precision Medicine programs around the world.
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12:00 |
Using Family Health History and Information Technology to Implement Precision Medicine in Primary Care
- Implementation of Comprehensive Family Health History Based Risk Stratification in Primary Care – the experience of MeTree
- Comprehensive risk stratification is an essential yet underutilised aspect of current primary care practice
- Patient-facing family health history-based risk stratification tools can improve guideline-concordant risk categorisation of patients
- With targeted clinical decision support, risk stratification tools can impact patient and provider behaviour
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Dr Ryanne Wu
Assistant Professor, Health Services & Systems Research Programme
Duke-NUS Medical School
Assistant Professor of Medicine
Center for Applied Genomics and Precision Medicine
Duke University
Dr. R. Ryanne Wu is an Internal Medicine physician and Health Services researcher with a focus on Implementation Science methodologies. She holds joint appointments as Assistant Professor in the Signature Program in Health Services and Systems Research at Duke-NUS Medical School and Assistant Professor of Medicine at Duke University in the United States. Dr. Wu completed her medical degree at the University of North Carolina-Chapel Hill, residency at Georgetown University, and fellowship in Internal Medicine and Health Services research at Duke University. Dr. Wu’s main research interest is risk stratification and risk counselling within medical care to improve tailoring of prevention, screening, and treatment strategies to the individual patient. She is a member of the Center for Applied Genomics and Precision Medicine at Duke University and the Center for Precision Medicine (PRISM) at Duke-NUS Medical School. She has been involved in the development and implementation of a family health history-based risk stratification tool, MeTree, in healthcare systems across the United States. She is currently evaluating the implementation of MeTree within the Singapore and exploring the intersection between family health history and genomic data. |
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12:45 |
Lunch & Networking |
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13:45 |
Enabling Precision Medicine with Big Data: Utilising Big Data in the Integration of Precision Medicine into Healthcare
- Explore how Big Data (Biostatistics, Predictive Analytics and Modelling Models) play key roles in Precision Medicine
- How to incorporate Genetic/ Risk Profiling derived from Big Data into Population Health Planning
- Case Study: Precision Public Health (The merging of phenotypic data & genomic data)
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Sanjeev Kumar
Industry Manager, Healthcare Asia Pacific
Frost & Sullivan
Sanjeev Kumar is an Industry Manager with the Healthcare Practice at Frost & Sullivan, Asia Pacific and has over nine years of consulting and analytics expertise, including research in areas such as pharmaceutical industry overview, therapeutic area research and diagnostic market research. His consulting expertise covers market intelligence, competitor analysis, market entry and distribution strategy.
He is sought after for his technical expertise base covering the key healthcare sectors from pharmaceuticals and biotechnology to clinical and molecular diagnostics matched by a strong background in statistical expertise and business intelligence. In addition, he has developed custom research in healthcare areas such as Clinical Trials, CRO CMO, Therapeutic Area research, Regenerative Medicine and Clinical Diagnostics.
Key projects he has worked on include Analysis of the Global & APAC Clinical trials and CRO Industry, Global CMO, Biologics Outsourcing market, Generics and Biosimilars and Immunochemistry Market. Research on therapeutic area such as Oncology, Diabetes and neurology.
He holds a Master of Business (Marketing) and a Bachelor of Pharmacy.
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14:15 |
How AI and Machine Learning is Driving Precision Medicine & Genomic Findings
- Discover the application & implication of AI in precision medicine, optimising treatment design on a patient-by-patient basis
- Predicting the Efficacy of Treatments by Using Artificial Intelligence in Precision Medicine
- Case Study: Develop a data-driven triage process to classify stroke patients and predict the efficacy of existing and novel treatments
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Sumanth Kambhammettu
Senior Manager – Health Industries
PwC Singapore
Sumanth provides strategy and operations consulting services to pharmaceutical companies, healthcare institutions, governments, medical technology and digital health companies in Asia. He specialises in the areas of growth strategy, go-to-market strategy, commercial strategy and new technology/adjacency assessments. His experience spans multiple therapy area analyses including oncology, immunology, infectious diseases and non-communicable diseases He has contributed to industry journals such asScrip, European Biopharmaceutical Review (EBR) and Contract Pharma and presented at events such as Biopharma Congress Asia (Singapore, 2010) and ViB events Biosimilars Congress(Brussels, 2008).
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14:45 |
The role of CRISPR in Precision Medicine
- Brief overview of current CRISPR state of the art
- Discover the potential of gene-editing technology (CRISPR-Cas-9) in clinical medicine
- Explore the use of CRISPR as a gene screening tool to identify novel drug targets
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Dr Quin Wills
Genomics Head
Major Research Hub
Dr Quin Wills is an experienced genomicist at the interdisciplinary interface of cellular genetics, with qualifications in medicine, mathematics, computational biology, and statistical genomics. Having previously co-founded a drug genomics CRO, and now leading a target discovery department, he has experience in both experimental, computational, and translational genomic science in the precision medicine space. Quin has taught a wide range of international courses in genomics and bioinformatics.
In addition to developing and supervising genomic software, Quin developed and lectured a series of R-based courses from exploratory data visualisation through to high throughput techniques and performance computing, aimed at multidisciplinary researchers.
Others: Developed and taught a workshop in `multi-scale biology’, University of British Columbia. Taught `statistics for genomics’, MIT. Co-developed and taught `introductory metabonomics’ workshop at the Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences. Guest seminars on computational biology at the Cambridge Computational Biology Institute. Conceived and led `biological data analysis and informatics’ workshop at the University of the Witwatersrand, South Africa. I’ve also consulted for the South African regional innovation agency on the development of a national competitive bioinformatics strategy.
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15:15 |
Afternoon Refreshment
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15:30 |
Precision Oncology with Radiogenomics: non-invasive interrogations of cancer genomics, immunomics and metabolic to select drug therapy and monitor response for optimal patient outcomes
- Emerging role of Radiomics in Precision Medicine
- How biomedical quantitative image analytic combined with genomics and clinical expertise can revolutionize cancer screening, prognosis and treatment planning
- Explore the potential of Radiomics in other cancer types and how it can improve cancer treatment
- Case Study: Developing Quantitative Cancer Imaging and Radiomics Applications for Liver Cancer Treatment
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Prof Pierce Chow
Senior Consultant Surgeon
NCCS & SGH
Professor
Duke-NUS Medical School
President
College of Clinician Scientists (CCS)
Pierce Chow is an academic surgeon and Professor at the Duke-NUS Medical School. He is concurrently Senior Consultant Surgeon at the National Cancer Centre Singapore and the Singapore General Hospital, NMRC Senior Clinician Scientist and Adjunct Faculty at the Genome Institute of Singapore. He trained in Liver Transplantation with Professor Russell Strong in Australia. In 1998, he co-founded the Asia-Pacific Hepatocellular Carcinoma (AHCC) Trials Group and has been the protocol chair of 5 multi-centre clinical trials that have involved more than 30 centres in 14 countries. He was conferred the NMRC National Outstanding Clinician Scientist Award for improving clinical outcomes with his research on Liver Cancer in 2012.
Prof Chow was awarded him the NMRC grant for the Translational and Clinical Research (TCR) Flagship Programme in Liver Cancer in 2016. Building on positive results of earlier genetic and immunology studies in surgically resected HCC, Prof Chow now leads a multi-national study on how genomic heterogeneity and the immune micro-environment in HCC impact clinical outcomes. The Programme will identify clonally dominant drivers, bring precision medicine to individuals with HCC and initiate new multi-national clinical studies across the Asia Pacific to advance treatment strategies for HCC.
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16:10 |
Leveraging Precision Medicine Today: Integrating Health Records with Genomic Data
- How to responsibly gather, study, share, report and utilise the massive amount of personal genomic information with an evidence-based framework
- Institute an Ethical Framework for Storing and Sharing Genomic Data – Can this be achieved with Singapore’s National Health Record?
- Data Sharing: Ensure Patient Rights and Privacy with Confidentiality & Protection Statements
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Dr Owen Schaefer
Research Assistant Professor: Centre for Biomedical Ethics (CbmE)
Yong Loo Lin School of Medicine, National University of Singapore
Owen Schaefer is a Research Assistant Professor at the Centre for Biomedical Ethics, National University of Singapore. He received his DPhil in Philosophy from Oxford University, and has completed fellowships at the National Institutes of Health’s Department of Bioethics and the Oxford Centre for Neuroethics. His primary interests lie on the ethics of developing novel biomedical technologies. He has written on ethical issues related to topics such as human subjects research, gene testing and editing, IVF (including mitochondrial replacement), and human enhancement. He is also currently serving as a Global Future Councils Fellow for the Council on the Future of Technology, Values and Policy, an initiative of the World Economic Forum.
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Dr Tamra Lysaght
Assistant Professor & Phase Director, Health Ethics, Law and Professionalism (HeLP), CbmE
Yong Loo Lin School of Medicine, NUS
My research interests lie broadly around the sociopolitical, ethical and regulatory issues surrounding stem cell innovation, regenerative medicines, precision medicine, genomics and reproductive technologies. I have expertise in empirical bioethics and experience in using both qualitative and quantitative research methods to inform normative questions pertaining to emergent biotechnologies and the biomedical sciences. I have worked on policy issues with the Committee for Ethics, Law and Society of the Human Genome Organisation, the Technical Working Group on Ethics at the World Health Organization, the Singapore Ministry of Health and Bioethics Advisory Committee. I am currently an Assistant Professor and Phase Director of the Health Ethics, Law and Professionalism (HeLP) Programme at the Centre for Biomedical Ethics, National University of Singapore. I hold multiple grants on projects examining the ethics and regulation of innovative stem cell-based therapies, and have research interests in governance issues surrounding the return of incidental findings and data sharing in precision medicine.
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16:50 |
Closing Remark by Conference Chairperson |
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17:00 |
Champagne Networking Session |
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After a long day of learning, benchmarking, and planning, unwind and mingle with your peers.
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